So, if you target specific macro ratios when cutting, you’ll end up under-eating protein, which can cost you muscle mass. This is because our energy needs change over time, but protein needs do not. Your macro percentage (or macro ratios) will change as you progress with a diet and bulk phase.Imagine a treatment and control group measured 5 times, then an intervention with 5 more observations. Create fake data set with given intercepts and slopes. SAS Code Fragments Analyzing changes in trend over time.